Replication fork directionality reveals how structural variants arise under replication stress
Dominik Głodzik, Mathilda Rigby, Michail Andreopoulos, Jake Crawford, Shannon R. Ehmsen, Avraam Tapinos, Alex Cornish, Richard S. Houlston, David C. Wedge, Ralph Scully, Peter J. Park
The paper identifies a novel mechanism for large tandem duplications in cancer by analyzing replication fork directionality and develops a classifier to distinguish SV phenotypes based on replication features.
bioRxiv · Jul 3, 2026 · PreprintBioinformatics