Hypoxia-enhanced Blood-Brain Barrier Chip recapitulates human barrier function, drug penetration, and antibody shuttling properties
Tae-Eun Park, Nur Mustafaoglu, Anna Herland, Ryan Hasselkus, Robert Mannix, Edward A. FitzGerald, Rachelle Prantil-Baun, Alexander Watters, Olivier Henry, Maximilian Benz, Henry Sanchez, Heather J. McCrea, Liliana Christova Goumnerova, Hannah W. Song, Sean P. Palecek, , Donald E. Ingber
This paper develops a BBB chip that maintains high barrier function for a week, enabling better drug and antibody testing.
bioRxiv · Nov 29, 2018 · PreprintBioengineering