Intraventricular infusion to circumvent the blood-brain barrier to gemcitabine.
Bruno Chauffert, Antoine Galmiche, Christophe Louandre, Bernard Royer, Michel Simonet, Nelly Guilain, Fabien Rech, Pierre Simonet, Maxime Sibert, Ahmed Abdaoui, Alexandre Cau, Mathieu Boone, Jacques Beaurain
This study demonstrates that intraventricular infusion of gemcitabine bypasses the blood-brain barrier in preclinical models, achieving therapeutic concentrations in brain tissue.
bioRxiv · May 5, 2026 · PreprintPharmacology & Toxicology