The Pregnane X Receptor (PXR) contributes to phenotypic plasticity and modulates the sensitivity to targeted therapies in melanoma
Stefan D Nicolescu, Alice Matheux, Marina Grimaldi, Nadia Vie, Raphaël Romero, Mathilde Robin, Eric Fabbrizio, Abdelhay Boulahtouf, Julia Toucheboeuf, Amélie Gudin-de-Vallerin, Florence Boissière, Fanny Leenhardt, Litaty Mbatchi, Laura Tallevast, Patrick Balaguer, , Philippe Pourquier
This study shows that PXR expression in melanoma cells increases sensitivity to BRAFi/MEKi treatment and is linked to a melanocytic phenotype.
bioRxiv · Nov 4, 2026 · PreprintCancer Biology