A chromatin fiber model explains cell-free DNA fragmentation signatures of active regulatory elements
Alexis Yang, Garyoung Gary Lee, Surya B. Chhetri, Razane El Hajj Chehade, Gunsagar Singh Gulati, Medha Pandey, Doris Fu, Yoo-Na Kim, Shahabeddin Sotudian, Hunter Savignano, Sadia D. Shahbazi, Chelsea Philpot, Taylor A. Hoggood, D. Gulhan, M Kellis, , Sylvan C. Baca
The paper infers enhancer activity from cfDNA fragmentation patterns and proposes a chromatin fiber model to explain these signatures.
bioRxiv · Nov 6, 2025 · PreprintGenomics