Deciphering human heart failure with preserved ejection fraction (HFpEF) at single cell resolution
Lukas Zanders, Simone-Franziska Glaser, Mariano Ruz Jurado, Moritz Brandt, David John, Luka Nicin, David Rodríguez Morales, Wesley Tyler Abplanalp, Tara Procida‐Kowalski, Franziska Ganß, Evelyn Ullrich, Alisa Debes, Penelope Pennoyer, Marek Bartkuhn, Reinhard B Dettmeyer, , Stefanie Dimmeler
This paper uses single-nucleus RNA sequencing to analyze HFpEF myocardium, identifying transcriptional changes in cardiomyocytes, endothelial cells, fibroblasts, and macrophages that suggest metabolic, inflammatory, and fibrotic mechanisms.
European Heart Journal · Nov 1, 2025Peer-reviewedCell Biology