Reprogramming VHL with molecular glues enables selective degradation of caspase-2
Jianzhong Hu, Weixian Deng, Shu Ou, Alex Golkar, Alison Inglis, Kate Smither, Shiqian Li, Kui Chen, Kelvin Frank Cho, Sung Jun Bae, Stephan Zech, Kaylee Choi, Willem den Besten, Stephanie Voß, Olivier Bedel, , Jaeki Min
This study develops VHL molecular glues that selectively degrade caspase-2, expanding the substrate range of VHL-based degraders and providing tools to study caspase-2's role in apoptosis and stress.
bioRxiv · Aug 17, 2026 · PreprintBiochemistry