CD28 Shapes T Cell Receptor Signaling by Regulating ZAP70 Activation and Lck Dynamics
Kumarkrishna Raychaudhuri, Rohita Rangu, Alison Ma, Neriah Alvinez, Andy D. Tran, Sandeep Pallikkuth, Katherine M. McIntire, Joseph A. Garvey, Jason Yi, Lawrence E. Samelson
This study shows CD28 co-stimulation accelerates ZAP70 recruitment and activation in TCR microclusters by enhancing Lck dynamics and spatial separation of Lck species.
Frontiers in Immunology · Dec 24, 2024Peer-reviewedImmunology