Enzyme Activation of Triggerable Polymeric Lysosome Targeting Chimeras
Badal Singh, Priyanath Das, Aniket Majee, Adam Tajdi, Anirudh Devarajan, Allison Lomeli, Amelia Talluri, Ranit Dutta, S. Thayumanavan
This paper introduces tPolyTACs, a covalent enzyme-responsive platform for extracellular protein degradation, showing enhanced selectivity and efficiency by using phosphatase-cleavable substrates to trigger lysosomal targeting.
bioRxiv · Sep 7, 2026 · PreprintCell Biology