A mosaic RBD-nanoparticle pan-sarbecovirus vaccine elicits nanobodies that target highly conserved epitopes
Kathryn E. Malecek, Jennifer R. Keeffe, Chengcheng Fan, Jaasiel Alvarez, Alyssa Player, Han Gao, Priyanthi N.P. Gnanapragasam, Semi Rho, Lisa M. Schimanski, Luisa N. Segovia, Tiong Kit Tan, Pamela J. Björkman
This study identifies nanobodies targeting conserved SARS-CoV-2 RBD epitopes that neutralize variants and zoonotic sarbecoviruses.
bioRxiv · Oct 15, 2026 · PreprintImmunology