Benchmarking Molecular Methods of Protein Engineering and Surveying Protein Search Space to Bolster Artificial Intelligence-Based Designs
Sivakumar Ramamoorthy, Ruby Browning, Joy Brandt, Kirin Tisdale, Alyssa Schultz, Maria Victoria Liendro Dalinger, Nick Hengartner, Daniel R. Tauritz, John Frederick Beckmann
The paper benchmarks molecular methods for protein engineering and evaluates AI-based designs by comparing mutagenesis and phenotypic screening of a fluorophore.
bioRxiv · Oct 22, 2026 · PreprintBioinformatics