Phenome-wide association studies (PheWAS) across large "real-world data" population cohorts support drug target validation
Dorothée Diogo, Chao Tian, Christopher S. Franklin, Mervi Alanne-Kinnunen, Michael March, Chris C. A. Spencer, Ciara Vangjeli, Michael E. Weale, Hannele Mattsson, Elina Kilpeläinen, Patrick M. Abou‐Sleiman, Dermot F. Reilly, Joshua J. McElwee, Joseph Maranville, Arnaub K. Chatterjee, , Heiko Runz
The paper uses PheWAS across large cohorts to identify genetic associations with drug targets and predict drug safety and efficacy.
bioRxiv · Nov 13, 2017 · PreprintGenetics