Chao Tian

This study identifies 49 genetic loci associated with sleep apnoea risk using multi-trait GWAS, with 29 replicated in a large cohort, and finds genetic correlations with several complex traits.

This paper conducts a multi-ancestry GWAS of major depression, identifying 190 loci and 354 genes, with findings showing increased fine-mapping power and bidirectional BMI relationship in European ancestry samples.

The paper identifies sex-differential participation bias in genetic studies by performing GWAS on sex in 3.3 million individuals, finding 158 loci associated with sex and highlighting traits like BMI that may influence participation.

This study identifies genetic loci associated with daytime napping and finds potential causal links between napping and cardiometabolic traits.

The paper identifies HLA-B*55:01 as a genetic risk factor for penicillin allergy through genome-wide analysis of electronic health records and imputed HLA data.

The paper compares DNA extraction and sequencing methods for formalin-preserved ancient cadaver samples, finding FFPE and high-throughput sequencing to be more effective.

This study identifies one known and two novel genetic variants associated with heart failure through GWAS and multi-omic analyses, revealing potential causal mechanisms and shared heritability with musculoskeletal traits.

The paper characterizes the prevalence and health consequences of uniparental disomy in four million individuals, identifying 675 cases and linking UPD of chromosome 22 to autism.

This study identifies two genetic loci, GDF5 and COL27A1, associated with knee pain through a genome-wide association analysis in the UK Biobank and replication in other cohorts.

This study conducts GWAS on impulsive personality traits and drug experimentation in 22,861 adults, identifying genetic associations and correlations with psychiatric disorders.

A meta-analysis of 807,553 people from 23andMe, UK Biobank and PGC finds 102 depression variants. 87 of them replicate in 1,306,354 individuals, and heritability is enriched in prefrontal brain regions.

This study shows common genetic variants significantly contribute to migraine family clustering, with higher burden in familial cases compared to population-based cases.

This study conducts a GWAS on depression phenotypes in UK Biobank, identifying genetic variants enriched in excitatory synaptic pathways.

This study investigates genetic mechanisms underlying sex bias in ADHD prevalence using genome-wide data and finds no mean polygenic burden difference across sexes but increased risk in female siblings and comorbid conditions.

The paper uses PheWAS across large cohorts to identify genetic associations with drug targets and predict drug safety and efficacy.

This study identifies susceptibility loci for multiple common infections through genome-wide association and HLA fine-mapping analyses in over 200,000 individuals.

This study replicates and extends findings of CADM2 and MSRA gene associations with personality traits using data from 23andMe.