Virus-associated Inflammation Imprints an Inflammatory Profile on Long-lived Monocyte-derived Macrophages in the Human Liver
Juan Diego Sanchez Vasquez, Shirin Nkongolo, Daniel Traum, Samuel C. Kim, Deeqa Mahamed, Aman Mehrotra, Anjali Patel, Diana Chen, Scott Fung, Anuj Gaggar, Jordan J. Feld, Kyong-Mi Chang, Jeffrey J. Wallin, Harry L.A. Janssen, Adam J. Gehring
The paper shows that chronic inflammation in the liver leads to the formation of long-lived inflammatory macrophages derived from monocytes, which retain an inflammatory profile and may drive liver disease progression.
bioRxiv · Jan 31, 2024 · PreprintImmunology