Author

Amanda Beccard

Broad Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Lindy E. BarrettiD· 3 shared Anne M. Bara· 2 shared Dane Z. HazelbakeriD· 2 shared Kevin C. EgganiD· 2 shared Aarno V. PalotieiD· 1 shared Aditi Trehan· 1 shared Alexander A. LobodaiD· 1 shared Andrea GannaiD· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Lindy E. BarrettORCID

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Author profile →

3 papers

Recent·Most cited

The 22q11.2 region regulates presynaptic gene-products linked to schizophrenia

Ralda Nehme, Olli P. H. Pietiläinen, Mykyta Artomov, Matthew Tegtmeyer, Vera Valakh, Leevi Lehtonen, Christina Bell, Tarjinder Singh, Aditi Trehan, J. L. Sherwood, Danielle K. Manning, Emily R. Peirent, Rhea Malik, Ellen J. Guss, Derek Hawes, , Kevin C. Eggan

This study investigates how the 22q11.2 deletion affects gene expression in neural progenitor cells and neurons, linking it to schizophrenia risk through altered presynaptic gene products.

Nature Communications · Jun 27, 2022Peer-reviewedNeuroscience

FMR1 loss results in early changes to intrinsic membrane excitability in human cellular models

Sara G. Susco, Mario A. Arias-García, Violeta G. López-Huerta, Amanda Beccard, Anne M. Bara, Jessica Moffitt, Justin A. Korn, Zhanyan Fu, Lindy E. Barrett

This study examines the effects of FMR1 loss on intrinsic membrane excitability in human cortical neurons using isogenic hPSC models, finding early and transient changes in electrophysiological properties.

Developmental Biology · Sep 22, 2020Peer-reviewedNeuroscience

Multiplexed and Inducible Gene Modulation in Human Pluripotent Stem Cells by CRISPR Interference and Activation

Dane Z. Hazelbaker, Amanda Beccard, Gabriella Angelini, Patrizia Mazzucato, Angelica Messana, Daisy Lam, Kevin C. Eggan, Lindy E. Barrett

The paper develops a stable, multiplexed CRISPRi/a system in hPSCs using fluorescent piggyBac vectors and inducible dCas9 transgenes to enable precise gene modulation and analysis.

Scientific Reports · Jan 20, 2020Peer-reviewedMolecular Biology