A DNM1L GTPase Effector Domain Deletion Causes Intermediate Defects in Peroxisomal and Mitochondrial Dynamics and Reveals a Targetable Metabolic Vulnerability
Saurabh Srivastav, Sharayu Jangam, Jonathan Andrews, Evangelos Theodorou, Lauren C. Briere, Gabriel D Quintana, Ingrid LS Gomes, Jonas A. Saute, Pranjali Bhagwat, Aanya Subramaniam, Neelanjana Roy, Ellen Macnamara, Amarilis Sanchez-Valle, Cecilia Gordillo, Hugo J. Bellen, , Michael F Wangler
This study investigates the functional impact of a DNM1L GED deletion variant, showing intermediate effects on peroxisomal and mitochondrial dynamics and a targetable metabolic vulnerability.
bioRxiv · Nov 4, 2026 · PreprintGenetics