Macrophage-induced rifampin tolerance across Mycobacterium tuberculosis lineages is Rv1258c-dependent
Kristin N. Adams, Amit Kumar Verma, Radha Gopalaswamy, Harresh Adikesavalu, Dinesh Kumar Singhal, Srikanth Tripathy, Uma Devi Ranganathan, David R. Sherman, Kevin B. Urdahl, Lalita Ramakrishnan, Rafael E. Hernandez
The paper shows that Rv1258c is required for rifampin tolerance in Mtb Lineage 4 strains but not isoniazid tolerance, and that other lineages develop rifampin tolerance except Lineage 2 Beijing strains.
bioRxiv · Aug 3, 2018 · PreprintMicrobiology