MDM2 stabilization of Notch intracellular domain upon DNA damage plays a major role in non-small cell lung carcinoma response to platinum chemotherapy
Sara Bernardo, Lisa J. Brunet, Quentin Dominique Thomas, David Bracquemond, Céline Bouclier, Marie Colomb, Maicol Mancini, Eric Fabbrizio, Alba Santos, Sylvia Fenosoa Rasamizafy, Amina-Milissa Maacha, Anais Giry, Emilie Bousquet, Laura Papon, Marion Goussard, , Antonio Maraver
This study identifies MDM2 stabilization of NICD in response to platinum chemotherapy in NSCLC, showing that targeting MDM2 and NICD improves survival and reduces tumor growth.
EMBO Molecular Medicine · Jan 16, 2026Peer-reviewedCancer Biology