Adult regenerative defects arise from discordant scaling of signal dependent growth and patterning
Pietro Tardivo, Fabrizio Olmeda, Martin Nuamah Asare, Jessica Lange, Dunja Knapp, Andre Fischer, Yuka Taniguchi‐Sugiura, Prayag Murawala, Édouard Hannezo, Elly Margaret Tanaka
The paper investigates how scaling of signaling pathways affects adult organ regeneration, finding that mismatched scaling of SHH and Wnt9a signaling prevents digit regeneration in large blastemas.
bioRxiv · Apr 29, 2026 · PreprintSystems Biology