The interface of malignant and immunologic clonal dynamics in high-grade serous ovarian cancer
Allen W. Zhang, Andrew McPherson, Katy Milne, David R. Kroeger, Phineas T. Hamilton, Alex Miranda, Tyler Funnell, Sonya Laan, Dawn R. Cochrane, Jamie L.P. Lim, Winnie Yang, Andrew Roth, Maia A. Smith, Camila de Souza, Julie Ho, , Sohrab P. Shah
The paper analyzes the interaction between tumor and immune clones in ovarian cancer, finding that immune contexture patterns mirror malignant spread and that foldback inversions correlate with poor outcomes.
bioRxiv · Oct 4, 2017 · PreprintCancer Biology