Author

Andrew Roth

Washington University in St. LouisPrimary ORCID profile (0000-0002-5490-8634 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

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Andrew RothiD2 papers · Texas A&M University

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Adrian N. C. Wan· 1 shared Alex MirandaiD· 1 shared Alexandre Bouchard-Côté· 1 shared Ali BashashatiiD· 1 shared Allen W. ZhangiD· 1 shared Amy Lopez· 1 shared Andreas Heindl· 1 shared Andrew McPhersoniD· 1 shared

Activity by Year

2017-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperCancer Biology

Adrian N. C. Wan

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2 papers

Recent·Most cited

Mycobacterium tuberculosis inactivates host oxysterols to impair macrophage cholesterol homeostasis

Andrew Roth, Mohsen Ali Asgari, Pallavi Chandra, Jalalah Muhammad, Amy Lopez, Sourav Bhattacharya, Isabelle A. Williams, Brian T. Edelson, Charles W. Goss, Dmitri Ivanovich Kotov, Mingxing Qian, Douglas F. Covey, 蒋巡天, William James Griffiths, Yuqin Wang, Jennifer A. Philips

This study identifies Mtb's enzymatic inactivation of host oxysterols as a mechanism to disrupt macrophage cholesterol homeostasis and generate treatment-responsive metabolic signatures in TB.

bioRxiv · Oct 5, 2026 · PreprintMicrobiology

The interface of malignant and immunologic clonal dynamics in high-grade serous ovarian cancer

Allen W. Zhang, Andrew McPherson, Katy Milne, David R. Kroeger, Phineas T. Hamilton, Alex Miranda, Tyler Funnell, Sonya Laan, Dawn R. Cochrane, Jamie L.P. Lim, Winnie Yang, Andrew Roth, Maia A. Smith, Camila de Souza, Julie Ho, , Sohrab P. Shah

The paper analyzes the interaction between tumor and immune clones in ovarian cancer, finding that immune contexture patterns mirror malignant spread and that foldback inversions correlate with poor outcomes.

bioRxiv · Oct 4, 2017 · PreprintCancer Biology