Refinement of the Pathogenic T Cell Receptor Motif Suggests Type 17 CD8+ T Cells Initiate HLA-B*27-associated Autoimmunity
Isabel Risch, Qingping Wu, Rahul Devkota, Sophia Y. Li, Joy Um, Tertuliano Alves Pereira Neto, Sarah Walden, Paulo Henrique Arantes de Faria, Andrei Belean, Lucy Durham, Michael Tang, Zoya Qaiyum, Robert Davies Inman, Leonie S. Taams, Xinbo Yang, , Michael Paley
The paper identifies a broader pathogenic T cell receptor motif linked to HLA-B*27-associated autoimmune diseases and shows these T cells express a Type 17 program.
bioRxiv · Sep 24, 2026 · PreprintImmunology