Caspofungin binding to iron compromises its antifungal efficacy against Candida albicans
Andreia Pedras, Cláudia Malta-Luís, Luı́s M. P. Lima, Dalila Mil‐Homens, Catarina Amaral, Américo G. Duarte, Wilson Antunes, Ana Gaspar‐Cordeiro, Ricardo O. Louro, Pedro Lamosa, Cláudio M. Soares, Diana Lousa, Catarina Pimentel
This study shows that iron binding to caspofungin reduces its antifungal efficacy against Candida albicans and other fungi in iron-overloaded conditions.
Communications Biology · Oct 8, 2025Peer-reviewedMicrobiology