DarHTG is a tripartite phage defence system for purine DNA base ADP-ribosylation
Raphael Ledermann, Anna-Lena Gotzler, Barbara Steigenberger, Yijun Wang, Johanna Zimmermann, Selina Geiger, Jieying Fu, Johannes Hoffmann, Osamu Suyari, YuGeng Zhang, Yang Lu, Andreja Mikoc, Christoph Tang, Ivan Ahel, Marion Schuller
The paper describes DarHTG, a bacterial phage defense system that ADP-ribosylates double-stranded DNA using a helicase co-toxin, and identifies two subclasses with distinct target bases.
bioRxiv · Nov 3, 2026 · PreprintMicrobiology