JAK2 signalling to HNRNPA1 represses retrotransposon activity in haematopoietic stem cells
Jeremy Deuel, Andrejs Makarovs, Sheidasadat Goosheh, George Winder, Hisham Mohammed, Jason S. Carroll, Michael Spencer Chapman, Chiraag D. Kapadia, Peter Campbell, Jyoti Nangalia, Elisa Laurenti, Constanze Schneider, Thomas Oellerich, Anthony Richard Green, Stephen J. Loughran
The paper identifies a JAK2-HNRNPA1 pathway that represses retrotransposon activity in haematopoietic stem cells, reducing insertional mutagenesis.
bioRxiv · Jul 7, 2025 · PreprintCell Biology