Temporal and cell-type specific SPAK-NKCC1 disruption following severe TBI in the developing gyrencephalic brain.
Alexandra Hochstetler, Ya’el Courtney, Peace Oloko, Benjamin Baskin, Andrew Ding-Su, Tawny Stinson, Elyssa Alber, David Y. Chung, Declan McGuone, Robin Haynes, Maria K. Lehtinen, Beth A. Costine
This study examines age-dependent changes in NKCC1 and SPAK expression following TBI in piglets, identifying potential therapeutic targets for pediatric TBI.
Acta Neuropathologica Communications · Feb 24, 2026Peer-reviewedNeuroscience