The Effects of Phosphorylation on the Structure and Function of Motif A, an Intrinsically Disordered Region within SIRT1
Sabrina M. Richter, Hoang-Long Bui, Addison Chen, Chloe Tannous, Benjamin R Butler, Sophia D Bennett, Samson Quang-anh Nguyen, Justin Prado, Ryan Nhan, Ayan Mohamed, Isaac A DuBois, Emile Tadros, Nhu Tam Thai, Selina Lima Guan, Carla Marie Peralta, , Ningkun Wang
This study investigates how phosphorylation affects the structure and function of motif A in SIRT1, showing that phosphomimetic mutation at Ser27 enhances SIRT1 activity and induces structural ordering of the disordered region.
Biochemistry · Jul 28, 2026Peer-reviewedBiochemistry