TOPII-targeting and MUS81 deficiency sensitise HER2-low tumour models to T-DXd
James Monypenny, Ceri Savage, Angela L. Caipa Garcia, Xiaolan Jiang, Gregory Weitsman, Marco Foiani, Tony Ng
This study identifies TopII targeting and MUS81 deficiency as sensitizers to T-DXd in HER2-low tumour models, showing increased cytotoxicity and DNA damage.
bioRxiv · Aug 6, 2026 · PreprintCancer Biology