Author

Angelo D. Meringa

Utrecht University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1

Frequent Co-Authors

Jurgen H. E. KuballiD· 3 shared Zsolt SebestyéniD· 3 shared Dennis X. BeringeriD· 2 shared Jeanine M.L. RoodhartiD· 2 shared Lucrezia C D E Gatti· 2 shared Maarten A. HuismansiD· 2 shared Péter BrázdaiD· 2 shared Sabine Heijhuurs· 2 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

Jurgen H. E. KuballORCID

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Author profile →

3 papers

Recent·Most cited

Functional γδT-omics pipeline reveals compartmentalization of Vδ1⁺ T cell migration, tumor-reactivity, and clonality in human colorectal cancer

Lucrezia C D E Gatti, Mara J.T. Nicolasen, Farid Keramati, Péter Brázda, Angelo D. Meringa, Dorine A. De Bont, Tineke Aarts‐Riemens, Willemijn J. C. Brandwijk, Maud I.M. van der Wijst, Anniek Stuut, Laia Gasull-Celades, Daniel Zawal, Konstantinos Vazaios, Annet Daudeij, Maarten A. Huismans, , Jurgen H. E. Kuball

The paper develops a γδT-omics pipeline to analyze compartmentalization of Vδ1⁺ T cell migration, tumor-reactivity, and clonality in human colorectal cancer, revealing distinct functional and transcriptional features across tumor compartments.

bioRxiv · Aug 19, 2025 · PreprintImmunology

Engineering BCMA CAR T cells for myeloma-targeted cargo delivery

Thomas Kimman, Marta Cuenca, Ralph Geoffrey Tieland, Dedeke Rockx-Brouwer, Jasmijn Janssen, Benjamin Motais, Anne Slomp, Corine Pleijte, Sabine Heijhuurs, Angelo D. Meringa, Wendy Boschloo, Douwe M. T. Bosma, Sanne Kroos, Vania Lo Presti, Joost P. G. Sluijter, , Victor Peperzak

This paper develops BCMA CAR T cells with a granzyme B-NOXA fusion to enhance apoptosis in multiple myeloma cells, improving killing efficacy in vitro and in xenograft models.

Nature Communications · May 19, 2025Peer-reviewedImmunology

Sensitivity to Vγ9Vδ2TCR T cells is imprinted after single mutations during early oncogenesis

Astrid Cleven, Angelo D. Meringa, Péter Brázda, Domenico Fasci, Thijs Koorman, Tineke Aarts‐Riemens, Inez Johanna, Dennis X. Beringer, Patricia Hernández-López, Sabine Heijhuurs, Tomohiro Mizutani, Sangho Lim, Maarten A. Huismans, Jochem H. Bernink, David Vargas Diaz, , Zsolt Sebestyén

This study shows that single mutations during early oncogenesis can upregulate BTN2A1, enabling Vγ9Vδ2 TCR binding, but full activation requires subsequent phosphorylation of BTN3A1.

bioRxiv · Nov 19, 2024 · PreprintCancer Biology