A Cherry-Flavoured E-Cigarette Adduct, BPGA, Reprograms Alveolar Epithelial Cell Fate Through Epithelial-to-Mesenchymal Transition and Evasion of Apoptosis
Joseph Xavier, Yuefan Yu, Bhavani Varma, Zhaolin Lu, Megha KB, Remya NS, Anil Kumar PR, Jorge Bernardino de la Serna
This study shows that BPGA, a cherry-flavoured e-cigarette adduct, induces oxidative stress, inflammation, and EMT-like changes in alveolar epithelial cells, potentially contributing to lung injury and fibrosis.
bioRxiv · May 14, 2026 · PreprintPharmacology & Toxicology