The Mycobacterium tuberculosis ESX effector promotes pyroptosis-dependent pathogenicity and dissemination
Yajie Shen, Yifan He, Xuehe Liu, Anke Chen, Lu Geng, Xuehe Liu, Yuhui Gao, Yuxin Qiu, Lu Zhang, Zhidong Hu, Yicheng Sun, Sheng‐ce Tao, Xiao‐Yong Fan, Hua Yang, 戈宝学, , Jixi Li
This study identifies EccB5 as a key Mtb effector that drives pyroptosis and enhances virulence by interacting with GSDMD and caspase-1.
Cell Death and Differentiation · Oct 28, 2026Peer-reviewedMicrobiology