Human progenitor T-cell differentiation regulated by the mechanical resistance of thymus-mimetic extracellular matrices
Nicholas C. Jeffreys, Kyle T Ruark, Joshua M. J. Price, Ella M Serrano-Wu, Blake F. Hanan, Andrew S. Khalil, Wei‐Hung Jung, Nuria Lafuente‐Gómez, Christina M. Tringides, Ann Gao, Joshua M. Brockman, Andrew Lu, Izabela Zmirska, Kyle Vining, Junzhe Lou, , David J. Mooney
This study shows that mechanical properties of thymus-mimetic matrices regulate human T-cell differentiation by modulating Notch1 and integrin signaling pathways.
Advanced Healthcare Materials · Jan 4, 2026Peer-reviewedBioengineering