Clinical history shapes the predictive value of polygenic risk
Dmitrii Usoltsev, Иван Игоревич Молотков, Nikita Kolosov, Mary Pat Reeve, Alexander Ukhatov, FinnGen, Oxana Rotar, Anna Kostareva, Konradi Alexandra, Samuli Ripatti, Aarno V. Palotie, Mark J. Daly, Mykyta Artomov
The paper develops and validates polygenic risk scores (PRS) for 150 diseases and mortality using UK Biobank and FinnGen data, showing genetic information provides the largest predictive gains for certain diseases but not others.
medRxiv · Sep 27, 2026 · PreprintGenetic & Genomic Medicine