Host membrane cholesterol constrains constitutive signaling of the oncogenic KSHV GPCR ORF74
Jun Bae Park, Amita Rani Sahoo, Annabelle Ryu, Matthias Buck, Jae Ung Jung
This study identifies a cholesterol-dependent mechanism by which the KSHV GPCR ORF74 regulates its constitutive activity through structural and functional analysis.
bioRxiv · Sep 23, 2026 · PreprintMicrobiology