Symmetrical Dimethylarginine as the Central Antigenic Determinant of Anti-Smith Autoantibodies in Systemic Lupus Erythematosus
Lars C. van Vliet, Annemarie L Dorjée, Martijn van der Heide, Annette Grummels, Esther van Andel, Gerda M. Steup-Beekman, Tom W. J. Huizinga, René E. M. Toes, Jolien Suurmond
This study identifies symmetrical dimethylarginine (sDMA) as the central antigenic determinant recognized by anti-Smith autoantibodies in SLE, showing their high cross-reactivity to sDMA-containing viral epitopes.
Annals of the Rheumatic Diseases · Jul 10, 2026Peer-reviewedImmunology