Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21
Xiaomei Li, Qingyang Wang, Anping Guo, Yaping Qiu, Qiuxia Chen, You Li, Lanjun Zhang, Yaxin Guo, Xiaoyun Meng, Shiqian Li, Guizhi Liu, Liyun Zhang, Jian Liu, Xianyang Li, Longying Cai, , Dengfeng Dou
This study identifies small-molecule ligands for TRIM21, an E3 ligase, demonstrating their ability to degrade nuclear pore complex proteins and induce cell death in cancer cells.
ACS Chemical Biology · Apr 18, 2025Peer-reviewedCell Biology