Author

Antonio Caldarelli

German Center for Neurodegenerative Diseases

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:clustering· 1 Research Focus:gene regulatory network inference· 1 Organism:non-human primate· 1

Frequent Co-Authors

Natalia Rodríguez‐MuelaiD· 3 shared Tobias GraßiD· 3 shared Zeynep DokuzluogluiD· 3 shared Fabian RostiD· 2 shared Ahmed ElewaiD· 1 shared Ana‐Maria OprişoreanuiD· 1 shared András SimoniD· 1 shared Anthony J. CesareiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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Focal author (center)Selected co-authorORCID co-authorUnlinked name

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3 shared papersNeuroscience

Natalia Rodríguez‐MuelaORCID

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Author profile →

4 papers

Recent·Most cited

Endogenous SMN Heterogeneity Defines Dynamic States of Motor Neuron Vulnerability and Resilience

Joshua Thomas, Antonia Ramme, Jungeun Yun, Antonio Caldarelli, Sofia Vrettou, Fabian Rost, Zeynep Dokuzluoglu, Tobias Graß, Brunhilde Wirth, Natalia Rodríguez‐Muela

This study identifies endogenous SMN protein heterogeneity as a determinant of motor neuron vulnerability and resilience, showing that SMN levels dynamically influence neuronal fate in disease models.

bioRxiv · Sep 29, 2026 · PreprintNeuroscience

Altered lysosomal biology impairs motor neuron survival via TFEB dysregulation in spinal muscular atrophy

Ines Rosignol, Zeynep Dokuzluoglu, Antonio Caldarelli, Ana‐Maria Oprişoreanu, Sofiia Ushakova, Tohid Siddiqui, Rahul Grover, Hannes Guerlich, Björn H. Falkenburger, Stefan Diez, Tobias Graß, Catherina Gwynne Becker, Natalia Rodríguez‐Muela

The paper shows that TFEB activation restores lysosomal function and improves motor neuron survival in SMA, highlighting its potential as a therapeutic target.

bioRxiv · Jul 7, 2025 · PreprintNeuroscience

Synchronous 3D patterning of diverse CNS progenitors generates motor neurons of broad axial identity

Felix Buchner, Zeynep Dokuzluoglu, Joshua D. Thomas, Antonio Caldarelli, Shrutika Kavali, Fabian Rost, Tobias Graß, Natalia Rodríguez‐Muela

The paper introduces a method to generate spinal motor neurons with diverse axial identities in human spinal cord organoids, enhancing their utility for studying neural development and disease.

bioRxiv · Dec 13, 2024 · PreprintNeuroscience

Telomerase-independent maintenance of telomere length in a vertebrate

Qinghao Yu, Phillip B. Gates, Samuel Rogers, Ivan Mikičić, Ahmed Elewa, Florian Salomon, Martina Lachnit, Antonio Caldarelli, Neftali Flores Rodriguez, Anthony J. Cesare, András Simon, Maximina Hee Yun

The paper shows that the newt Pleurodeles waltl maintains telomeres without telomerase, using ALT for whole-organism telomere length preservation.

bioRxiv · Mar 25, 2022 · PreprintMolecular Biology