MOTS-c Coordinates Inter-Organellar Proteostasis for Adaptation to Chronic Metabolic Stress
Conscience P. Bwiza, Ella Schwab, Lily Xia, Ariana Chen, Elijah Song, Sabrina Lin, E Sle Kim, Yui Hashiyada, JM Son, Michelle C. Rice, Jessica Kim, Sara Martins, Eun Hee Koh, Bérénice Anath Benayoun, Changhan Lee
This study identifies MOTS-c as a mitochondrial-derived peptide that coordinates inter-organellar proteostasis to enable adaptation to chronic metabolic stress.
bioRxiv · Jun 23, 2026 · PreprintCell Biology