Epigenetic reprogramming by promoter hypomethylation is linked to aberrant gene expression and transcriptomic plasticity in colorectal cancer
Luís Nunes, Ina A. Eilertsen, Rita Pinto, Hege M. Vedeld, Ingrid M. Bolstad, Usman Saeed, Ole H. Sjo, Sheraz Yaqub, Arild Nesbakken, Kushtrim Kryeziu, Guro E. Lind, Ragnhild A. Lothe, Anita Sveen
The paper identifies promoter hypomethylation as a driver of transcriptomic plasticity and aberrant gene expression in colorectal cancer, linking it to distinct cell states and metastatic behavior.
bioRxiv · Nov 5, 2026 · PreprintGenomics