Decoding stress-induced adaptation of cancer cells in spatial confinement by integrating live-cell imaging and mathematical modeling
Gopal Vyankatesh Kulkarni, ATISH MOHANTY, Ayalur Raghu Subbalakshmi, Arin Nam, Sourabh Kotnala, Dana Do, Prakash Kulkarni, Mohit Kumar Jolly, Supriyo Bhattacharya, Ravi Salgia
This study combines live-cell imaging and mathematical modeling to show how cancer cells adapt to stress in spatially confined environments, revealing cooperative and competitive strategies influenced by spatial organization and microenvironment dynamics.
bioRxiv · Nov 2, 2026 · PreprintCancer Biology