IgG4 antibody repertoire diversity is stable over several years in health and autoimmune disease
Linus Wollenweber, Laurent M. Paardekooper, Yvonne J M Campman, Jessica M van Bokkum, Martijn Rudolf Tannemaat, Jan J.G.M. Verschuuren, Arjan Barendregt, Albert J. R. Heck, Albert Bondt, Maartje G. M. Huijbers
The paper examines IgG4 antibody repertoire stability over time in health and autoimmune diseases, finding that most clones remain stable despite treatment.
bioRxiv · Oct 6, 2026 · PreprintImmunology