What comes after de novo? Automated lead optimization of proteins with CRADLE-1
Eli Bixby, Gino Brunner, Daniel Danciu, Richard Dela Rosa, Nicolas Deutschmann, Constance Ferragu, Franziska Geiger, Christian Holberg, Patrick Kidger, Arthur Lindoulsi, Noé Lutz, Thomas McColgan, Sebastian Millius, Harmen van Rossum, Jinel Shah, , Angela I. Schriek
CRADLE-1 automates protein lead optimization, improving speed and efficiency compared to rational design methods.
bioRxiv · Oct 16, 2026 · PreprintBioengineering