Thienothiazolocarboxamides: rapidly cidal agents causing catastrophic thiol collapse in Mycobacterium tuberculosis.
Sangmi Oh, Gareth Prosser, Helena I.M. Boshoff, Simon Richard Green, Neha Quadir, Jose Santinni O. Roma, Ashish Kumar, Nilesh Mukundan, Sarah Hanson, Jansy Passiflora Sarathy, Kirsteen I Buchanan, Peter C. Ray, Paul G. Wyatt, Thomas R. Ioerger, Adrian L. Schwan, , Clifton E. Barry
This paper identifies thienothiazolocarboxamides as rapidly cidal antituberculosis agents that cause thiol collapse in Mycobacterium tuberculosis through EthA-mediated activation.
bioRxiv · Nov 9, 2026 · PreprintMicrobiology