Co-Stimulatory Blockade Prevents Intragraft Accrual of Class-Switched, Activated B Cells Despite Failing to Prevent T-Cell Mediated Rejection
J. Timothy Caldwell, Tiffany Shi, Ashley R. Burg, Ashley Koby, Krishna M. Roskin, Anna L. Peters, Erica A. K. DePasquale, E. Steve Woodle, David A. Hildeman
The paper investigates the effects of co-stimulatory blockade on B cell accrual and T cell subsets during T-cell-mediated renal allograft rejection using single-cell RNA sequencing.
bioRxiv · Oct 24, 2025 · PreprintImmunology