Phosphoproteomics profiling of the monocytes uncovers the mechanosensory pathways regulating monocytes responses to pathologic level of shear stress
Austin Lai Lai, Chanly Chheang, Haoyun Fang, Habiba Danish, Yasmin Mirzaalikhan, Nalin H. Dayawansa, Anna M.D. Watson, Jonathan Edward Noonan, Ching-Seng Ang, David W. Greening, Karlheinz Peter, Sara Baratchi
This study identifies mechanosensory pathways in monocytes exposed to pathological shear stress, revealing PKC and Piezo1 as key regulators of monocyte phenotype and function in calcific aortic valve disease.
bioRxiv · Oct 7, 2026 · PreprintCell Biology