Synthetic BiologyACS Synthetic BiologyPeer-reviewed
CRISPRi-Linked Multi-Module Negative Feedback Loops to Address Winner-Take-All Resource Competition
Sadikshya Rijal, Kylie Standage-Beier, Rong Zhang…·Xiao‐Jun Tian
This study introduces a CRISPRi-based controller to mitigate Winner-Take-All behavior in synthetic gene circuits by promoting balanced module activation through negative feedback.
4 citations