Palmitate-activated IRE1-XBP1 signaling limits DNA damage and is associated with H2A.X-linked DNA damage response transcripts in triple-negative breast cancer cells
Kevin Y. Chen, Elaina Gouin, Ava Erickson, Yogit Goyal, Samantha Zaloudek, Sean Foster, Caleb T. Sandum, S. Patrick Walton, Christina Chan
This study shows that palmitate-activated IRE1-XBP1 signaling reduces DNA damage in triple-negative breast cancer cells by regulating H2A.X and DNA-damage-response transcripts.
bioRxiv · Sep 28, 2026 · PreprintCancer Biology