Lysosomal permeabilization by Group A Streptococcus releases proteins into the macrophage cytosol
Ava Quezada, Kevin Lord, Cheldon Ann Alcantara, Claire M. Delahunty, Kevin Kim, Olivia Okamoto, John R. Yates, Cheryl Y. M. Okumura
This study shows that Group A Streptococcus perforates macrophage phagolysosomes, releasing both host and bacterial proteins into the cytosol, which triggers inflammatory responses and contributes to disease pathology.
Infection and Immunity · Apr 30, 2026Peer-reviewedMicrobiology