Investigating EMT-mediated resistance to EGFR tyrosine kinase inhibitors in NSCLC using innovative organoid models
Nobuaki Kobayashi, Seigo Katakura, Nobuhiko Fukuda, Shuhei Teranishi, Sousuke Kubo, Chisato Kamimaki, Hiromi Matsumoto, Kohei Somekawa, Ayami Kaneko, Yoshihiro Ishikawa, Koji Okudela, Keisuke Sekine, Takeshi Kaneko
This study investigates EMT-mediated resistance to EGFR TKIs in NSCLC using organoid models, finding links between EMT markers and resistance, and suggesting potential therapeutic strategies.
bioRxiv · Feb 8, 2024 · PreprintCancer Biology