Author

Ayan Malakar

Children's Hospital of Philadelphia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetic & Genomic Medicine· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant effect prediction· 1 Assay:whole-exome sequencing· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Ali G. GharaviiD· 1 shared Andrew S. AlleniD· 1 shared Atlas Kahn· 1 shared Catherine A. BrownsteiniD· 1 shared Cathy Lee MendelsohniD· 1 shared Chunhua WengiD· 1 shared David B. GoldsteiniD· 1 shared Elicia A. EstrellaiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperGenetic & Genomic Medicine

Ali G. GharaviORCID

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2 papers

Recent·Most cited

Interstitial Cystitis: a phenotype and rare variant exome sequencing study

Joshua E. Motelow, Ayan Malakar, Sarath Babu Krishna Murthy, Miguel Verbitsky, Atlas Kahn, Elicia A. Estrella, Wanqing Shao, Louis M. Kunkel, Madelyn Wiesenhahn, Jaimee Beckett, Natasha Harris, Richard Lee, R. M. Adam, Kamil E. Barbour, Hakon H. Hakonarson, , Catherine A. Brownstein

This study uses exome sequencing to identify genetic associations with interstitial cystitis/bladder pain syndrome, finding new links and extending known associations.

EBioMedicine · Feb 18, 2026Peer-reviewedGenetic & Genomic Medicine

Ancestry adjustment improves genome-wide estimates of regional intolerance

Tristan J. Hayeck, Nicholas Stong, Evan H. Baugh, Ryan S. Dhindsa, Tychele N. Turner, Ayan Malakar, Timothy L. Mosbruger, Grace Tzun-Wen Shaw, Yuncheng Duan, Iuliana Ionita‐Laza, David B. Goldstein, Andrew S. Allen

This study shows that adjusting for ancestry improves genome-wide estimates of regional intolerance by incorporating demographic history, leading to better variant classification.

Genetics · Apr 6, 2022Peer-reviewedGenetics